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1

Structural basis of thalidomide enantiomer binding to cereblon

Mori, Tomoyuki, Ito, Takumi, Liu, Shujie, Ando, Hideki, Sakamoto, Satoshi, Yamaguchi, Yuki, Tokunaga, Etsuko, Shibata, Norio, Handa, Hiroshi, Hakoshima, Toshio

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 6.35 MB

english, 2018

2

Gibberellin-induced DELLA recognition by the gibberellin receptor GID1

Murase, Kohji, Hirano, Yoshinori, Sun, Tai-ping, Hakoshima, Toshio

Journal:

Year:

2008

Language:

english

File:

PDF, 1021 KB

english, 2008

3

Molecular Mechanism for the Regulation of Rho-Kinase by Dimerization and Its Inhibition by Fasudil

Hiroto Yamaguchi, Miyuki Kasa, Mutsuki Amano, Kozo Kaibuchi, Toshio Hakoshima

Journal:

Year:

2006

Language:

english

File:

PDF, 938 KB

english, 2006

4

Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts

Takashi Yoshizawa, Yoshiyuki Hattori, Motoki Hakoshima, Kimiko Koga, Yoshie Maitani

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2008

Language:

english

File:

PDF, 516 KB

english, 2008

5

[Part 2: Biological Sciences] || Molecular Structure of a Double Helix That Has Non-Watson--Crick Type Base Pairing Formed by 2-Substituted Poly(A) and Poly(U)

Toshio Hakoshima, Toshikazu Fukui, Morio Ikehara and Ken-Ichi Tomita

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 1.28 MB

english, 1981

6

The molecular structure of a DNA-triostin A complex

Wang, A., Ughetto, G, Quigley, G., Hakoshima, T, van der Marel, G., van Boom, J., Rich, A

Journal:

Year:

1984

Language:

english

File:

PDF, 1.57 MB

english, 1984

7

MT1-MMP recognition by ERM proteins and its implication in CD44 shedding

Terawaki, Shin-ichi, Kitano, Ken, Aoyama, Miki, Mori, Tomoyuki, Hakoshima, Toshio

Journal:

Year:

2015

Language:

english

File:

PDF, 1.72 MB

english, 2015

8

Structural basis of the specific interactions of GRAS family proteins

Hakoshima, Toshio

Journal:

Year:

2018

Language:

english

File:

PDF, 1.27 MB

english, 2018

9

ChemInform Abstract: Dechloroacutumine from Cultured Roots of Menispermum dauricum.

Yukihiro Sugimoto, Shinobu Inanaga, Masako Kato, Toshiyuki Shimizu, Toshio Hakoshima, Akira Isogai

Journal:

Year:

1999

File:

PDF, 26 KB

1999

10

Tributyl(3,3,3-trifluoro-1-propynyl)stannane as an Efficient Reagent for the Preparation of Various Trifluoromethylated Heterocyclic Compounds.

Takeshi Hanamoto, Yuhko Hakoshima, Mikio Egashira

Journal:

Year:

2005

File:

PDF, 141 KB

2005

11

Measurement of flow velocity distribution by multiple-exposure speckle photography

K. Iwata, T. Hakoshima, R. Nagata

Journal:

Optics Communications

Year:

1978

Language:

english

File:

PDF, 221 KB

english, 1978

12

Tributyl(3,3,3-trifluoro-1-propynyl)stannane as an efficient reagent for the preparation of various trifluoromethylated heterocyclic compounds

Takeshi Hanamoto, Yuhko Hakoshima, Mikio Egashira

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

13

Dechloroacutumine from cultured roots of menispermum dauricum

Yukihiro Sugimoto, Shinobu Inanaga, Masako Kato, Toshiyuki Shimizu, Toshio Hakoshima, Akira Isogai

Journal:

Year:

1998

Language:

english

File:

PDF, 181 KB

english, 1998

14

Polyamine interaction with Z-DNA

K. Tomita, T. Hakoshima, K. Inubushi, S. Kunisawa, H. Ohishi, G.A. van der Marel, J.H. van Boom, A.H.-J. Wang, A. Rich

Journal:

Journal of Molecular Graphics

Year:

1989

Language:

english

File:

PDF, 410 KB

english, 1989

15

Use of a fusion protein to obtain crystals suitable for X-ray analysis: Crystallization of a GST-fused protein containing the DNA-binding domain of DNA replication-related element-binding factor, DREF

Munekazu Kuge, Yoshifumi Fujii, Toshiyuki Shimizu, Toshio Hakoshima, Fumiko Hirose, Akio Matsukage

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 401 KB

english, 1997

16

Crystal structure of decameric peroxiredoxin (AhpC) from Amphibacillus xylanus

Ken Kitano, Akiko Kita, Toshio Hakoshima, Youichi Niimura, Kunio Miki

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2005

Language:

english

File:

PDF, 687 KB

english, 2005

17

Mechanical properties and microstructure of β-SiAION-β-SiC composites by pressureless sintering

C. Yamagishi, K. Tsukamoto, J. Hakoshima, H. Shimojima, Y. Akiyama

Journal:

Journal of Materials Science

Year:

1992

Language:

english

File:

PDF, 1.65 MB

english, 1992

18

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation

Keigo Gohda, Toshio Hakoshima

Journal:

Journal of Computer-Aided Molecular Design

Year:

2008

Language:

english

File:

PDF, 1.54 MB

english, 2008

19

Successive methyl migrations occurring in the acid treatment of 1-epoxyethyl-1,2,2-trimethyl-cyclopentane derivative

Isao Kitagawa, Hirotaka Shibuya, Hiromichi Fujioka, Yoshio Yamamoto, Akiharu Kajiwara, Kunihiro Kitamura, Ayako Miyao, Toshio Hakoshima, Ken-ichi Tomita

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 200 KB

english, 1980

20

Combination of RET siRNA and irinotecan inhibited the growth of medullary thyroid carcinoma TT cells and xenografts via apoptosis

Kimiko Koga, Yoshiyuki Hattori, Mihoko Komori, Ryota Narishima, Masahiro Yamasaki, Motoki Hakoshima, Tetsuya Fukui, Yoshie Maitani

Journal:

Year:

2010

Language:

english

File:

PDF, 572 KB

english, 2010

21

Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay

Keisuke Hamada, Masato Kato, Toshiyuki Shimizu, Kentaro Ihara, Takeshi Mizuno, Toshio Hakoshima

Journal:

Year:

2005

Language:

english

File:

PDF, 426 KB

english, 2005

22

Crystal structure of human Rad GTPase of the RGK-family

Arry Yanuar, Shigeru Sakurai, Ken Kitano, Toshio Hakoshima

Journal:

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

23

Structural basis of PSGL-1 binding to ERM proteins

Yumiko Takai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima

Journal:

Year:

2007

Language:

english

File:

PDF, 1.26 MB

english, 2007

24

10.1038/82822

Hakoshima, Toshio, Fujii, Yoshifumi, Shimizu, Toshiyuki, Toda, Takashi, Yanagida, Mitsuhiro

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 1.12 MB

english, 2000

25

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module

Terawaki, Shin-ichi, Kitano, Ken, Mori, Tomoyuki, Zhai, Yan, Higuchi, Yoshiki, Itoh, Norimichi, Watanabe, Takashi, Kaibuchi, Kozo, Hakoshima, Toshio

Journal:

The EMBO Journal

Year:

2009

Language:

english

File:

PDF, 2.89 MB

english, 2009

26

Structural basis for recruitment of human flap endonuclease 1 to PCNA

Sakurai, Shigeru, Kitano, Ken, Yamaguchi, Hiroto, Hamada, Keisuke, Okada, Kengo, Fukuda, Kotaro, Uchida, Makiyo, Ohtsuka, Eiko, Morioka, Hiroshi, Hakoshima, Toshio

Journal:

The EMBO Journal

Year:

2004

Language:

english

File:

PDF, 667 KB

english, 2004

27

N-glycan structures of murine hippocampus serine protease, neuropsin, produced in Trichoplusia ni cells

Noriko Takahashi, Yoshinori Tsukamoto, Sadao Shiosaka, Tadaaki Kishi, Toshio Hakoshima, Yoji Arata, Yoshiki Yamaguchi, Koichi Kato, Ichio Shimada

Journal:

Glycoconjugate Journal

Year:

1999

Language:

english

File:

PDF, 162 KB

english, 1999

28

Novel irinotecan-loaded liposome using phytic acid with high therapeutic efficacy for colon tumors

Yoshiyuki Hattori, Li Shi, Wuxiao Ding, Kimiko Koga, Kumi Kawano, Motoki Hakoshima, Yoshie Maitani

Journal:

Journal of Controlled Release

Year:

2009

Language:

english

File:

PDF, 850 KB

english, 2009

29

Structural Basis for NHERF Recognition by ERM Proteins

Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima

Journal:

Year:

2006

Language:

english

File:

PDF, 1.12 MB

english, 2006

30

Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN

Ken Kitano, Sun-Yong Kim, Toshio Hakoshima

Journal:

Year:

2010

Language:

english

File:

PDF, 2.12 MB

english, 2010

31

Increase in nucleolytic activity of ribonuclease T1 by substitution of tryptophan 45 for tyrosine 45

Satoshi NISHIKAWA, Hiroshi MORIOKA, Tsuyoshi KIMURA, Yukari UEDA, Toshiki TANAKA, Seiichi UESUGI, Toshio HAKOSHIMA, Ken-ichi TOMITA, Eiko OHTSUKA, Morio IKEHARA

Journal:

Year:

1988

Language:

english

File:

PDF, 748 KB

english, 1988

32

Measurement of flow velocity distribution by means of double-exposure holographic interferometry

Iwata, Koichi, Hakoshima, Tsuyoshi, Nagata, Ryo

Journal:

Journal of the Optical Society of America

Year:

1977

Language:

english

File:

PDF, 806 KB

english, 1977

33

Crystallographic Characterization of a PHO4-DNA Complex

Toshio Hakoshima, Yasuhiro Teranishi, Takeshi Ohira, Kenji Suzuki, Masato Shimizu, Masahiro Shirakawa, Yoshimasa Kyogoku, Nobuo Ogawa, Yasuji Oshima

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 298 KB

1993

34

Structural conversion between open and closed forms of radixin: low-angle shadowing electron microscopy

Hiroaki Ishikawa, Atsushi Tamura, Takeshi Matsui, Hiroyuki Sasaki, Toshio Hakoshima, Shoichiro Tsukita, Sachiko Tsukita

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 361 KB

english, 2001

35

Crystallization and Preliminary X-Ray Analysis of Neuropsin, a Serine Protease Expressed in the Limbic System of Mouse Brain

Tadaaki Kishi, Masato Kato, Toshiyuki Shimizu, Keiko Kato, Kazumasa Matsumoto, Shigetaka Yoshida, Sadao Shiosaka, Toshio Hakoshima

Journal:

Journal of Structural Biology

Year:

1997

Language:

english

File:

PDF, 106 KB

english, 1997

36

Crystallographic Characterization of the DNA-Binding Domain of Interferon Regulatory Factor-2 Complexed with DNA

Masahiro Kusumoto, Yoshifumi Fujii, Yuko Tsukuda, Takeshi Ohira, Yoshimasa Kyougoku, Tadatsugu Taniguchi, Toshio Hakoshima

Journal:

Journal of Structural Biology

Year:

1998

Language:

english

File:

PDF, 117 KB

english, 1998

37

Crystallographic Characterization of a Stress-Induced Multifunctional Protein, Rat HBP-23

Shoko Hirotsu, Yasuko Abe, Noriyuki Nagahara, Hiroyuki Hori, Takeshi Nishino, Kengo Okada, Toshio Hakoshima

Journal:

Journal of Structural Biology

Year:

1999

Language:

english

File:

PDF, 72 KB

english, 1999

38

Biochemical and Crystallographic Characterization of a Rho Effector Domain of the Protein Serine/Threonine Kinase N in a Complex with RhoA

Ryoko Maesaki, Toshiyuki Shimizu, Kentaro Ihara, Shinya Kuroda, Kozo Kaibuchi, Toshio Hakoshima

Journal:

Journal of Structural Biology

Year:

1999

Language:

english

File:

PDF, 97 KB

english, 1999

39

Glu 46 of ribonuclease T1 is an essential residue for the recognition of guanine base

S. Nishikawa, T. Kimura, H. Morioka, S. Uesugi, T. Hakoshima, K. Tomita, E. Ohtsuka, M. Ikehara

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 724 KB

english, 1988

40

Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex

Hirofumi Ohishi, Shoko Kunisawa, Gijs van der Marel, Jacques H. van Boom, Alexander Rich, Andrew H.-J. Wang, Ken-ichi Tomita, Toshio Hakoshima

Journal:

Year:

1991

Language:

english

File:

PDF, 412 KB

english, 1991

41

Molecular cloning, nucleotide sequence and expression of the tufB gene encoding elongation factor Tu from Thermus thermophilus HB8

Motohide Satoh, Toshikazu Tanaka, Akira Kushiro, Toshio Hakoshima, Ken-ichi Tomita

Journal:

Year:

1991

Language:

english

File:

PDF, 319 KB

english, 1991

42

Non-cognizable ribonucleotide, 2′AMP, binds to a mutant ribonuclease T1 (Y45W) at a new base-binding site but not at the guanine-recognition site

Toshio Hakoshima, Takeshi Itoh, Keigo Gohda, Ken-ichi Tomita, Sei-ichi Uesugi, Satoshi Nishikawa, Hiroshi Morioka, Eiko Ohtsuka, Morio Ikehara

Journal:

Year:

1991

Language:

english

File:

PDF, 821 KB

english, 1991

43

Interaction between the left-handed Z-DNA and polyamine-2: The crystal structure of the d(CG)3 and spermidine complex

Hirofumi Ohishi, Isao Nakanishi, Kouichi Inubushi, Gijs van der Marel, Jacques H. van Boom, Alexander Rich, Andrew H.J. Wang, Toshio Hakoshima, Ken-ichi Tomita

Journal:

Year:

1996

Language:

english

File:

PDF, 329 KB

english, 1996

44

Three-dimensional structure of a mutant ribonuclease T1 (Y45W) complexed with non-cognizable ribonucleotide, 2′AMP, and its comparison with a specific complex with 2′GMP

Toshio Hakoshima, Takeshi Itoh, Ken-ichi Tomita, Keigo Goda, Satoshi Nishikawa, Hiroshi Morioka, Sei-ichi Uesugi, Eiko Ohtsuka, Morio Ikehara

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 3.66 MB

english, 1992

45

Structural Basis of the Cytoplasmic Tail of Adhesion Molecule CD43 and Its Binding to ERM Proteins

Yumiko Takai, Ken Kitano, Shin-ichi Terawaki, Ryoko Maesaki, Toshio Hakoshima

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 957 KB

english, 2008

46

The crystal structure of N1-[2-(2-amino-ethylamino)-ethyl]-ethane-1,2-diamine (polyamines) binding to the minor groove of d(CGCGCG)2, hexamer at room temperature

Hirofumi Ohishi, Kenji Suzuki, Masahiro Ohtsuchi, Toshio Hakoshima, Alexander Rich

Journal:

Year:

2002

Language:

english

File:

PDF, 365 KB

english, 2002

47

Interaction between left-handed Z-DNA and polyamine — 3 The crystal structure of the d(CG)3 and thermospermine complex

Hirofumi Ohishi, Noriko Terasoma, Isao Nakanishi, Gijs van der Marel, Jacques H. Van Boom, Alexander Rich, Andrew H.-J. Wang, Toshio Hakoshima, Ken-ichi Tomita

Journal:

Year:

1996

Language:

english

File:

PDF, 397 KB

english, 1996

48

Interaction between the CheY response regulator and the histidine-containing phosphotransfer (HPt) domain of the ArcB sensory kinase in Escherichia coli

Hidenobu Yaku, Masato Kato, Toshio Hakoshima, Masakatsu Tsuzuki, Takeshi Mizuno

Journal:

Year:

1997

Language:

english

File:

PDF, 505 KB

english, 1997

49

Insights into Multistep Phosphorelay from the Crystal Structure of the C-Terminal HPt Domain of ArcB

Masato Kato, Takeshi Mizuno, Toshiyuki Shimizu, Toshio Hakoshima

Journal:

Year:

1997

Language:

english

File:

PDF, 1.51 MB

english, 1997

50

The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1

Ryoko Maesaki, Kentaro Ihara, Toshiyuki Shimizu, Shinya Kuroda, Kozo Kaibuchi, Toshio Hakoshima

Journal:

Year:

1999

Language:

english

File:

PDF, 664 KB

english, 1999

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